Efficacy of Platelet-Rich Plasma Injection on Ronge of Motion, Pain and Disability in Patients with Adhesive Capsulitis: A Systematic Review and Meta-analysis

Dr Wolff’s Opinion:

This article reviewed published data regarding the effectiveness of PRP vs Steroid and other treatment modalities for adhesive capsulitis. It found that PRP shoulder joint injections may provide better long-term benefit than steroid injections.

Adhesive capsulitis, sometimes better known as frozen shoulder, is a common condition that affects 2-5% of the population.  It is associated with gradual reduction of shoulder range of motion associated with increasing pain. Common treatments include physical therapy, and traditionally corticosteroid injections. Steroid injections may provide quick short term symptomatic relief by reducing inflammation. However, there are associated potential negative side effects including detrimental effects on articular cartilage and soft tissue. In comparison, PRP releases growth factors essential to the healing process. Platelets provide sustained release of anti-inflammatory factors, release growth factors that increase activity of a patient’s own stem cells and enhance the healing process. This ultimately provides long term benefit.

This study reviewed the therapeutic effects of PRP injection versus steroid injection on range of motion, pain and disability in patients with adhesive capsulitis (frozen shoulder). It found no significant differences at one month, but PRP had significantly better outcomes with improved range of motion, decreased pain and disability at three and six months. There were no associated complications. In comparison, the steroid treated group had gradually decreased benefits over time.

 

Cite: Archives of Physical Medicine and Rehabilitation 2023;104: 2109-22. Ho-Wei Line MS, Ka-Wai Tam, MD, PhD, et al.